Golnaz Karoubi, PhD

Scientist, Latner Thoracic Research Laboratories, University Health Network

Assistant Professor, University of Toronto;

Department of Laboratory Medicine & Pathobiology

Department of Mechanical Engineering

Lung and Airway Tissue Engineering and Regenerative Medicine – Acute and chronic airway and lung disease, represent a major health care problem. Research interests focus on the use of tissue engineering approaches, biomimetic culture systems, and stem cells for lung and airway repair and regeneration with the goal to engineer clinically applicable therapeutic strategies for end-stage lung disease. Studies include: (1) generation of biomimetic 3D organoid and culture systems for airway epithelium; (2) application of pluripotent stem cell-derived lung epithelial cells for airway regeneration; (3) cell-based therapeutic applications for end-stage lung disease (with focus on Pulmonary Fibrosis and Cystic Fibrosis); and (4) decellularization/recellularization approaches for development of bioengineered airway grafts.