Tereza Martinu, MD, MHSc

Clinician Scientist, Toronto Lung Transplant Program, UHN

CLAD team, in collaboration with the Juvet Laboratory

Scientist, Toronto General Hospital Research Institute

Associate Professor, University of Toronto: Temerty Faculty of Medicine, Institute of Medical Science, Immunology

Our group focuses on chronic lung allograft dysfunction (CLAD), the major cause of death beyond one year after lung transplantation. We apply single cell transcriptomics, proteomics, flow cytometry and microscopy imaging approaches to novel mouse models of CLAD, human lung-derived samples generously provided by our patients, as well as in-vitro cell culture systems. These strategies are used to study immune pathways, epithelial injury, and fibrosis in CLAD pathogenesis. Our goal is to elucidate mechanisms of CLAD and identify novel diagnostic and therapeutic targets for this condition.